| Osteogenesis Imperfecta Type V |
-
OI Type V is moderate in severity. It is similar to OI Type IV in terms of frequency of fractures and the degree of skeletal deformity.
-
The most conspicuous feature of this type is large, hypertrophic calluses in the largest bones at fracture or surgical procedure sites.
-
Hypertrophic calluses can also arise spontaneously.
-
Calcification of the interosseous membrane between the radius and ulna restricts forearm rotation and may cause dislocation of the radial head.
-
Women with OI Type V anticipating pregnancy should be screened for hypertrophic callus in the iliac bone.
-
OI Type V is dominantly inherited and represents 5 percent of moderate-to-severe OI cases.
|
| Osteogenesis Imperfecta Type VI |
-
OI Type VI is extremely rare. It is moderate in severity and similar in appearance and symptoms to OI Type IV.
-
This type is distinguished by a characteristic mineralization defect seen in biopsied bone.
-
The mode of inheritance is probably recessive, but it has not yet been identified.
|
|